Prevalence of Spastic Cerebral Palsy in Children with Congenital Talipes Equinovarus and Its Association with Ankle Foot Functional Performance
DOI:
https://doi.org/10.61919/620tpe37Keywords:
Congenital Talipes Equinovarus; Cerebral Palsy; Spastic Diplegia; GMFCS; Modified Ashworth Scale; Foot and Ankle Disability Index; Orthoses.Abstract
Background: Congenital talipes equinovarus (CTEV) frequently co-occurs with neuromotor disorders such as spastic cerebral palsy (CP), yet the relative contributions of static deformity versus neuromotor severity to ankle-foot function remain unclear. Objective: To determine the burden of spastic CP among children with CTEV and examine the association between neuromotor severity and ankle-foot functional performance. Methods: In an analytic cross-sectional study at tertiary rehabilitation/orthopedic clinics in Faisalabad over 10 months, consecutive children aged 5-15 years with CTEV underwent standardized assessments: CP subtype, Gross Motor Function Classification System (GMFCS), spasticity via Modified Ashworth Scale (MAS), CTEV severity via Pirani components, and ankle-foot function via the Foot and Ankle Disability Index (FADI). Primary outcomes were spastic CP burden and FADI; secondary analyses tested associations using χ²/t tests and regression adjusted for age, sex, bilaterality, and orthosis use (α=0.05). Results: Of 104 participants (mean age 6.95±2.80 years; 51% female), spastic CP was predominantly diplegic (81.7%), with bilateral CTEV in 90.4% and high rates of rigid equinus (left 92.3%, right 97.1% moderate/severe). Severe functional disability was common (FADI <40 in 76.0%). CP subtype strongly associated with functional disability (Cramer’s V 0.970; p<0.001), whereas structure-function correlations were weak (Spearman ρ −0.133; p=0.179). Adjusted models identified GMFCS and MAS as principal determinants of FADI. Conclusion: In CTEV, ankle-foot function is driven more by neuromotor severity than by static deformity; management should prioritize neuromotor-informed, function-focused programs integrating spasticity control, task-oriented training, and orthotic optimization.
References
1. Rosenbaum P, Paneth N, Leviton A, Goldstein M, Bax M, Damiano D, et al. A Report: The Definition and Classification of Cerebral Palsy April 2006. Dev Med Child Neurol Suppl. 2007;109:8–14.
2. Sadowska M, Sarecka-Hujar B, Kopyta I. Cerebral Palsy: Current Opinions on Definition, Epidemiology, Risk Factors, Classification and Treatment Options. Neuropsychiatr Dis Treat. 2020;16:1505–18.
3. Vitrikas K, Dalton H, Breish D. Cerebral Palsy: An Overview. Am Fam Physician. 2020;101(4):213–20.
4. Patel DR, Bovid KM, Rausch R, Ergun-Longmire B, Goetting M, Merrick J. Cerebral Palsy in Children: A Clinical Practice Review. Curr Probl Pediatr Adolesc Health Care. 2024;101673.
5. Johnston MV, Hoon AH Jr. Cerebral Palsy. Neuromolecular Med. 2006;8(4):435–50.
6. Marret S, Vanhulle C, Laquerriere A. Pathophysiology of Cerebral Palsy. Handb Clin Neurol. 2013;111:169–76.
7. MacLennan AH, Thompson SC, Gecz J. Cerebral Palsy: Causes, Pathways, and the Role of Genetic Variants. Am J Obstet Gynecol. 2015;213(6):779–88.
8. Chen D, Huang M, Yin Y, Gui D, Gu Y, Zhuang T, et al. Risk Factors of Cerebral Palsy in Children: A Systematic Review and Meta-Analysis. Transl Pediatr. 2022;11(4):556–65.
9. Oskoui M, Coutinho F, Dykeman J, Jetté N, Pringsheim T. An Update on the Prevalence of Cerebral Palsy: A Systematic Review and Meta-Analysis. Dev Med Child Neurol. 2013;55(6):509–19.
10. Barrie A, Varacallo M. Clubfoot. In: StatPearls [Internet]. Treasure Island FL: StatPearls Publishing; 2023.
11. Pavone V, Chisari E, Vescio A, Lucenti L, Sessa G, Testa G. The Etiology of Idiopathic Congenital Talipes Equinovarus: A Systematic Review. J Orthop Surg Res. 2018;13:1–11.
12. Smythe T, Rotenberg S, Lavy C. The Global Birth Prevalence of Clubfoot: A Systematic Review and Meta-Analysis. EClinicalMedicine. 2023;63:102180.
13. Mustari MN, Faruk M, Bausat A, Fikry A. Congenital Talipes Equinovarus: A Literature Review. Ann Med Surg Lond. 2022;81:104394.
14. Conner BC, Remec NM, Michaels CM, Wallace CW, Andrisevic E, Lerner ZF. Relationship Between Ankle Function and Walking Ability for Children and Young Adults With Cerebral Palsy: A Systematic Review of Deficits and Targeted Interventions. Gait Posture. 2022;91:165–78.
15. Horsch A, Klotz MCM, Platzer H, Seide S, Zeaiter N, Ghandour M. Is the Prevalence of Equinus Foot in Cerebral Palsy Overestimated? Results From a Meta-Analysis of 4814 Feet. J Clin Med. 2021;10(18):4128.
16. Stebbins J, Harrington M, Thompson N, Zavatsky A, Theologis T. Gait Compensations Caused by Foot Deformity in Cerebral Palsy. Gait Posture. 2010;32(2):226–30.
17. Paulson A, Vargus-Adams J. Overview of Four Functional Classification Systems Commonly Used in Cerebral Palsy. Children Basel. 2017;4(4):30.
18. Leigheb M, Rava E, Vaiuso D, Samaila EM, Pogliacomi F, Bosetti M, et al. Translation, Cross-Cultural Adaptation, Reliability, and Validation of the Italian Version of the Foot and Ankle Disability Index. Acta Biomed. 2020;91(4-S):160–8.
19. Harvey N, Daley D, Mudge A, Sims S, Adams R. Reliability of Physiotherapists Using the Pirani Scoring System for Clubfoot. Int J Ther Rehabil. 2012;19(8):439–47.
20. Pandyan AD, Johnson G, Price C, Curless R, Barnes M, Rodgers H. A Review of the Properties and Limitations of the Ashworth and Modified Ashworth Scales as Measures of Spasticity. Clin Rehabil. 1999;13(5):373–83.
21. Harb A, Kishner S. Modified Ashworth Scale. In: StatPearls [Internet]. Treasure Island FL: StatPearls Publishing; 2023.
22. Ricardo D, Raposo MR, Cruz EB, Oliveira R, Carnide F, Veloso AP, et al. Effects of Ankle Foot Orthoses on the Gait Patterns in Children with Spastic Bilateral Cerebral Palsy: A Scoping Review. Children Basel. 2021;8(10):903.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Ayesha Khalid, Ayza Zainab (Author)

This work is licensed under a Creative Commons Attribution 4.0 International License.