Role of Cucumis melo agrestis fruit extract in prevention and control of Acid Peptic Disease(APD)
DOI:
https://doi.org/10.61919/bvjmcq69Keywords:
Cucumis melo agrestis, acid peptic disease, functional dyspepsia, herbal extract, randomized controlled trialAbstract
Background: Acid peptic disease (APD) results from an imbalance between gastric acid secretion and mucosal defense mechanisms, leading to inflammation or ulceration of the stomach, duodenum, or esophagus. Current therapies provide partial relief and may cause relapse or adverse effects, underscoring the need for safe, plant-based alternatives. Cucumis melo agrestis (CM) fruit contains bioactive compounds with antioxidant and anti-inflammatory properties that may support mucosal healing. Objective: To evaluate the efficacy and safety of CM extract in preventing and controlling APD compared with placebo. Methods: A randomized, double-blind, placebo-controlled, multicenter trial was conducted among 100 adults with APD diagnosed using Rome IV criteria. Participants received either CM extract (5 µg/5 mL, thrice daily for six weeks) or a placebo. Outcomes were measured using the Gastrointestinal Symptom (GIS) score at baseline, 24 hours, and weeks 2, 4, and 6. Statistical analyses employed mixed-effects modeling and paired t-tests. Results: CM extract produced a rapid reduction in GIS scores within 24 hours (mean change −9.7, p < 0.001) and near-complete symptom resolution by week 6 (mean change −55.8, p < 0.001). Laboratory and safety parameters remained stable. Conclusion: CM extract demonstrated potent, sustained, and well-tolerated gastroprotective effects, supporting its potential as a safe, low-cost therapeutic adjunct for APD
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Copyright (c) 2025 Maaz Ahmad, Hamna Ahmad, Mussab Ahmad, Tehreem Munir (Author)
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