Correlation Between Quadriceps Muscles Strength and Functional Disability in Patients with Knee Osteoarthritis
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Abstract
Background: Knee osteoarthritis is a common chronic musculoskeletal disorder associated with pain, stiffness, quadriceps weakness, mobility limitation, and reduced functional performance. Quadriceps muscle strength is clinically important for knee stability and activities of daily living, but local evidence regarding its association with functional disability remains limited. Objective: To determine the correlation between bilateral quadriceps muscle strength and functional disability among patients with knee osteoarthritis. Methods: A cross-sectional observational study was conducted among 60 patients with knee osteoarthritis recruited through convenience sampling. Pain intensity was assessed using the Visual Analogue Scale, functional disability was measured using the Western Ontario and McMaster Universities Osteoarthritis Index, and quadriceps muscle strength was assessed through Manual Muscle Testing. Data were analyzed using SPSS version 25. Normality was assessed using Kolmogorov-Smirnov and Shapiro-Wilk tests, and Spearman’s rank-order correlation was used because key variables were not normally distributed. Results: The mean age of participants was 52.90 ± 4.77 years, and the mean body mass index was 29.76 ± 3.60 kg/m². Mean pain during walking was higher than pain at rest. Bilateral quadriceps strength showed strong negative correlations with WOMAC pain (rho = -0.950), WOMAC stiffness (rho = -0.904), WOMAC function (rho = -0.946), and total WOMAC score (rho = -0.946), all with p < 0.001. Conclusion: Lower quadriceps muscle strength was strongly associated with greater pain, stiffness, and functional disability in patients with knee osteoarthritis. Quadriceps strength assessment should be considered an important component of clinical evaluation and rehabilitation planning.
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1. Wada O, Kurita N, Kamitani T, Nakano N, Mizuno K. Influence of the severity of knee osteoarthritis on the association between leg muscle mass and quadriceps strength: the SPSS-OK study. Clin Rheumatol. 2019;38(3):719-725.
2. Geng R, Li J, Yu C, Zhang C, Chen F, Chen J, et al. Knee osteoarthritis: current status and research progress in treatment. Exp Ther Med. 2023;26(4):481.
3. Bacon KL, Segal NA, Øiestad BE, Lewis CE, Nevitt MC, Brown C, et al. Concurrent change in quadriceps strength and physical function over five years in the Multicenter Osteoarthritis Study. Arthritis Care Res. 2019;71(8):1044-1051.
4. Zuha A, Anees S, Usman Jameel M, Hashim A. Association of quadriceps femoris muscle weakness with symptomatic osteoarthritis of knee. Pak Biomed J. 2022.
5. Marks R. Muscle atrophy and knee osteoarthritis joint status: highlights and their implications, 2017-2023. Acta Sci Orthop. 2023.
6. Chen W, Li C, Wang Y, Shen X, Wu Z, Li J, et al. Comparison of the asymmetries in muscle mass, biomechanical property and muscle activation asymmetry of quadriceps femoris between patients with unilateral and bilateral knee osteoarthritis. Front Physiol. 2023;14:1126116.
7. Çokar D, Yıldız S, Şahinkaya T, Dinçer Ş, Gözübüyük ÖB, Özgönenel L. Comparison of quadriceps exercise modalities on pain, muscle strength, function, and balance in bilateral knee osteoarthritis. Istanbul Med J. 2022;23:6-11.
8. Shumnalieva R, Kotov G, Monov S. Obesity-related knee osteoarthritis-current concepts. Life (Basel). 2023;13(8).
9. Sadeghi A, Rostami M, Khanlari Z, Zeraatchi A, Jalili N, Karimi Moghaddam A, et al. Effectiveness of muscle strengthening exercises on the clinical outcomes of patients with knee osteoarthritis: a randomized four-arm controlled trial. Caspian J Intern Med. 2023;14(3):433-442.
10. Khan SA, Parasher P, Ansari MA, Parvez S, Fatima N, Alam I. Effect of an integrated physiotherapy protocol on knee osteoarthritis patients: a preliminary study. Healthcare (Basel). 2023;11(4).
11. O’Reilly SC, Jones A, Muir KR, Doherty M. Quadriceps weakness in knee osteoarthritis: the effect on pain and disability. Ann Rheum Dis. 1998;57(10):588-594.
12. Serrão PRMS, Gramani-Say K, Lessi GC, Mattiello SM. Knee extensor torque of men with early degrees of osteoarthritis is associated with pain, stiffness and function. Braz J Phys Ther. 2012;16.
13. Sonnery-Cottet B, Ripoll T, Cavaignac E. Prevention of knee stiffness following ligament reconstruction: understanding the role of arthrogenic muscle inhibition. Orthop Traumatol Surg Res. 2024;110(1 Suppl):103784.
14. Oda S, Izumi M, Takaya S, Tadokoro N, Aso K, Petersen KK, et al. Promising effect of visually-assisted motor imagery against arthrogenic muscle inhibition: a human experimental pain study. J Pain Res. 2021;14:285-295.
15. White MS, Kogan F, Delp SL, Chu CR, Sherman SL, S AP, et al. BMI and varus malalignment compound to define a high-risk phenotype for compartment-specific knee osteoarthritis progression. medRxiv. 2026.
16. Dos Anjos T, Gabriel F, Vieira TD, Hopper GP, Sonnery-Cottet B. Neuromotor treatment of arthrogenic muscle inhibition after knee injury or surgery. Sports Health. 2024;16(3):383-389.
17. Ibrahim T, Ahmed AF, Nofal M, Hegazy A, Ghomrawi HMK. Metabolic syndrome and the likelihood of knee pain and functional disability: evidence from a large Middle Eastern population-based study. BMC Musculoskelet Disord. 2023;24(1):634.
18. Wallace IJ, Worthington S, Felson DT, Jurmain RD, Wren KT, Maijanen H, et al. Knee osteoarthritis has doubled in prevalence since the mid-20th century. Proc Natl Acad Sci U S A. 2017;114(35):9332-9336.
19. Chang AH, Lee JJ, Chmiel JS, Almagor O, Song J, Sharma L. Association of long-term strenuous physical activity and extensive sitting with incident radiographic knee osteoarthritis. JAMA Netw Open. 2020;3(5):e204049.
20. Cao Z, Li Q, Li Y, Wu J. Causal association of leisure sedentary behavior with arthritis: a Mendelian randomization analysis. Semin Arthritis Rheum. 2023;59:152171.
21. Acar M, Sonmezer E, Yosmaoglu H. Factors associated with kinesiophobia in patients with knee osteoarthritis. Aktuelle Rheumatol. 2022;47.