Association of Cyanoacrylate-Based Eye Cosmetics With Allergic Blepharitis, A Cross-Sectional Study

Abstract

Background: Cyanoacrylate-based eye cosmetic adhesives, including eyelash extension adhesives and artificial lash glues, are increasingly used for cosmetic enhancement but may expose the eyelid margin and ocular surface to irritant or allergenic compounds. Objective: This study aimed to determine the association between cyanoacrylate-based eye cosmetic adhesive use and clinically diagnosed allergic blepharitis among young adult females and to assess whether frequency and duration of use were associated with eyelid inflammation and tear film instability. Methods: An analytical cross-sectional study was conducted among 73 females aged 18–35 years, including 37 users and 36 non-users of cyanoacrylate-based eye cosmetics. Data were collected using a structured proforma, symptom severity assessment, slit-lamp examination, Tear Break-Up Time test, Schirmer I test, and ocular surface pH assessment. Data were analyzed using SPSS version 26. Results: Allergic blepharitis was diagnosed in 29 participants (39.7%) and was more frequent among users than non-users (62.2% vs. 16.7%; OR = 8.21, 95% CI: 2.73–24.67). Frequency of use was significantly associated with allergic blepharitis, χ²(3, N = 73) = 22.684, p = 0.002, while duration of use was significantly associated with eyelid inflammation, χ²(3, N = 73) = 11.632, p = 0.009. Users had significantly lower mean TBUT than non-users (8.38 ± 2.06 vs. 10.44 ± 2.10 seconds; p < 0.001). Conclusion: Cyanoacrylate-based eye cosmetic adhesive use was significantly associated with allergic blepharitis and reduced tear film stability among young adult females, particularly with frequent and prolonged use.